When it comes to drugs, comedian Chelsea Handler will "try anything," she tells Salon. From microdosing on mushrooms to traveling to Peru to try ayahuasca, Handler wants to continue experimenting.

"If it's a drug that has a spiritual correlation, or can open your mind, like microdosing with mushrooms, is interesting to me, I do that a lot," Handler told SalonTV's D. Watkins. "They're doing microdosing with LSD now, I've never done that, but I would do it. I like anything that makes you start accessing a part of your brain that's kinda sleeping."

In the comedian's latest memoir "Life Will Be the Death of Me," she gets honest about her past year of "self-sufficiency," all triggered by the ascension of Trump.

Watch the video above to hear about why she would do ayahuasca again and the full episode with Chelsea Handler to hear her open up about losing her brother and why a year of looking inward convinced her to write a memoir.